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| Huifang Hu (胡慧芳)PostDoc. PhD awarded from Tsinghua University E-mail: huhuifang14@126.com Protein kinases play fundamental roles in numerous processes of lives. Dysregulation of protein kinases leads to diverse health problems from cancers to immunological and metabolic diseases. Thus, protein kinases are major potential targets for therapy purpose. My project focuses on exploring actions of several protein kinase families, such as p21-activated protein kinases (PAKs), AMP-activated protein kinases (AMPK) and SnRKs in Arabidopsis, using biochemistry, structural biology and enzymatic catalytic kinetics. The efforts anticipate to unveil the mystery of the molecular activation/inhibition events of the protein kinases for potential novel drug development. |
| Yanghui Ye (叶杨慧)PostDoc. PhD awarded from Zhejiang University E-mail: yhye@suda.edu.cn Bacteria exert extensive impacts on life and health, industrial and agricultural production, and environmental remediation. Understanding how bacteria survive and die in response to lethal stress will shed light on therapies of bacterial infectious diseases and utilization of microbial resource. Our previous work indicated that several typical antimicrobials stimulate a self-destructive process driven by reactive oxygen species (ROS) in bacteria under aerobic conditions when they harbor the primary damage specific to an antibiotic. Next, we put efforts on uncovering the mysterious veil of bacterial cell death upon exposure to damage-causing stressors under anaerobic conditions. |
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